Eriodictyol induced anticancer and apoptotic effects in human pancreatic cancer cells.

Abstract

Despite many studies over the past several decades, pancreatic cancer has known as one of the most vulnerable cancers. Apoptosis is considered one of the well-known treatment options for various cancer treatment research methods. Eriodictyol, a plant-derived flavonoid found in citrus fruits has been known to have diverse biological activities such as anti-oxidant, anti-cancer, and anti-inflammatory properties. In this study, we have investigated the anticancer property of eriodictyol and its mechanisms of action in pancreatic cancer cells. Eriodictyol induced apoptosis in both SNU213 and Panc-1 cells. Also, we found that eriodictyol has reduced the level of phosphorylation in AKT, and ERK. Furthermore, eriodictyol has increased the phosphorylation level of JNK. These results can help to discover the molecular mechanisms of eriodictyol-induced cell death in pancreatic cancer cell lines and potentially contribute to the development of candidate reagents for pancreatic cancer.