척수손상 실험모델 재현성을 위한 충격장치에 관한 연구

Abstract

Spinal cord injury signifies a state whose damage in spinal cord occurred in car accident, falling and careless exercise, resulting in symptons from sensory paralysis to acroparalysis. With purpose on remedy of spinal cord injury, many researchers have started to focus on experimental animal model. This is because a experimental research utilizing laboratory animals not only requires short time to experimentalize, but also enables effectiveness of remedy to be illustrated. In spinal cord injury experiment, prerequisite of laboratory animal is physiological feature similar to human, which must be able to reproduce lesion of spinal cord injury, anatomical, and ethological aspect regarding human. Accelerated impactor and injury apparatus hitting lab animals' spinal cord is intentionally used to reproduce the human spinal cord damage. Thus far, this machines has shortcoming which does not output enough reliable data to analyze reproduction. On this study to make up for this shortcoming, new spinal cord injury device(Robo Cylinder Impactor, RCI) has been developed with better accuracy, and precision to enhance reproduction. This impactor's suitability has been gauged by performance tests. Orthogonal robot applied for RCI system are able to move on exactly desired place after calculating image and distance data derived from sensors. Moreover, by using superior electric cylinder, a desired degree of spinal cord injury can be controlled by user. Compare to a previous impactor, these merits improve reproduction as well as enable a degree of damage to be estimated through qualification process of impulse. Performance test has been processed by using the developed machine on this study. Comparing the output data of the contusion experiment with previous experiment data, an availability of creating experimental animal model of spinal cord injury has been analyzed. Lastly, by figuring out a solution of problems caused from this experiment, a suitable control mode is suggested.