Babesia gibsoni 자연 감염견에서의 Atovaquone/Proguanil 합제와 Azithromycin 병용 투여에 따른 치료 효과

Abstract

This study was performed to estimate evaluate the clinical use of combination therapy with atovaquone/proguanil and azithromycin combination as an equivalent treatment in dogs naturally infected with Babesia gibsoni. Eight mixed-dogs infected naturally with B. gibsoni were used in this study. Four dogs of experimental group (No. 1-4) were received atovaquone/proguanil and azithromycin therapy and the other four dogs of control group (No. 5-8) were administered diminazene aceturate. All the dogs in this study showed mild to severe anemia and thrombocytopenia. B. gibsoni in blood smears was also disappeared after initiation of treatment. All of the experinmental group PCR analysis showed negative results during the observation period, but more than 1 dog of control group PCR analysis showed continuous positive results during the observation period. In this study, we evaluate therapeutic effectiveness of atovaquone/proguanil and azithromycin combination drug therapy. atovaquone/proguanil and azithromycin combination drug therapy can significantly lower B. gibsoni parasite levels and the results suggest that the therapeutic protocol is a new candidate for effective treatment in dogs infected with B. gibsoni.