수단그라스로부터 항산화 및 항균 활성 성분 규명

Abstract

Sorghum × drummondii (Nees ex Steud.) Millsp. & Chase was investigated for anti-oxidative and Anti-bacterrial activities. The dried Sorghum × drummondii was extracted for 24 hour with 70% ethanol. The obtained extract was successively partitioned into n-hexane (Hex), ethyl acetate (EtOAc), n-butanol (BuOH) and water (H2O) fractions. For the anti-oxidation tests, the ethanol extract, EtOAc, BuOH and H2O fractions showed good DPPH and ABTS+ radical scavenging activities. The total phenolic contents for the extract and solvent layers (Hex, EtOAc, BuOH, water) were estimated as 34.0, 36.3, 136.0, 39.3 and 17.7 mg (GAE/1 mg) respectively. In Anti-bacterrial activities, the Hex fration, EtOAc fration showed the considerable inhibition for Propionibacterium acnes and Staphylococcus epidermis. Therefore, futher phytochemical studies were conducted for the ethyl acetate fraction, which led to isolation of four constituents such as p-hydroxybenzaldehyde (1), Luteolin (2), Luteoloside (3) apigenin (4). All of the compounds were isolated for the first time from this plant.