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Phenylacetaldehyde, a volatile flavorand aromacompound, inhibits breast cancer stem cells through the blockade of Stat3/IL-6 signaling pathway

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Author(s)
강지영
Issued Date
2017
URI
http://dcoll.jejunu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000007916
Abstract
Breast cancer is the most common cancer in the world and a major leading cause of cancer deaths in women.Although the availability of diverseeffective therapies hasimproved survival rates,treating breast cancer is still considerable challenges due to the existence of CSCs. CSCs represent capable of treatment resistance, disease recurrence, and metastasis. In this study, we evaluated the PAA, a flavor and aroma volatile compound, for its efficacy to inhibit breast CSCs. Our results showed that PAA treatment significantly inhibited breast cancer cell proliferation, migration and colony formation. In addition, PAA induced the apoptosis of breast cancer cells and suppressed tumor growth in vivo.PAA reduced the mammosphere forming ability of breast cancer cells, the CD44high/CD24lowsubpopulationand the percentage of ALDH+cells. PAA also decreasedthe expression of self-renewal genesincluding Nanog, Sox2, Oct4 and CD44 as well as induced ROS activity. Furthermore, PAA blocked the Stat3 signaling pathway viainhibition ofnuclear Stat3 phosphorylationand IL-6secretion. Taken together, our findings suggest that PAA has anti-cancer and anti-CSC activitiesin breast cancer cells.This study provides evidence that PAA may improve the limitedeffects of breast cancer therapy.
Alternative Title
휘발성 향기 물질 phenylacetaldehyde의 Stat3/IL-6 경로 차단을 통한 유방암 줄기세포 억제 효과
Affiliation
제주대학교 일반대학원
Department
대학원 차세대융복합과학기술협동과정
Advisor
이동선
Awarded Date
2017. 2
Table Of Contents
CONTENTSⅰ.
LIST OF FIGURESⅱ.
ABSTRACT ⅲ.
1. Introduction 1
2. Materials and Methods 3
3. Results 8
3.1. PAA inhibits multiple cancer hallmarks in breast cancer cells. 8
3.2. PAA suppresses growth of breast tumors in vivo. 11
3.3. PAA treatment inhibits breast CSCs. 13
3.4. PAA reduced the percentage of CD44high/CD24lowand ALDH+ breast cancer cells. 15
3.5. PAA decreased self-renewal gene expression in breast CSCs and proliferation of mammospheres. 17
3.6. PAA inhibits the Stat3 signaling pathway and IL-6 secretion in breast CSCs. 19
4. Discussion 22
References 24
Degree
Master
Publisher
제주대학교 일반대학원
Citation
강지영. (2017). Phenylacetaldehyde, a volatile flavorand aromacompound, inhibits breast cancer stem cells through the blockade of Stat3/IL-6 signaling pathway
Type
Dissertation
Appears in Collections:
General Graduate School > Interdisciplinary Graduate Program in Advanced Convergence Technology and Science
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