제주도 원주민과 이주민의 담석증 유병률 및 위험인자에 대한 연구

Abstract

Objective The eating habits of Jeju island natives (JNs) are quite different from those of the mainland people due to geographic isolation. Diet is one of the main factors affecting the gallstone disease (GD). We investigated the prevalence of GD in both JNs and Jeju island migrants (JMs) and studied the risk factors affecting GD among Jeju island people. Methods After the IRB approval was obtained by our institution, this study enrolled a total of 20,763 subjects who underwent medical check-ups at the Health Promotion Center of Jeju National University Hospital in Korea from January 2003 to December 2015. They were examined by the ultrasonography if they had gallbladder stones or not. The body mass index, biochemical parameters, including liver function test results, lipid profile, and fasting blood glucose levels were checked, Age, birthplace (JNs vs. JMs), and sex variables were collected based on their medical records. Univariate and multivariate analyses were performed to identify the risk factors affecting GD. Results The prevalence of GD in the Jeju island people was 4.0%; Jeju island natives, 3.8% and migrants, 4.4% (P= 0.047). In the multivariate logistic regression analysis, the independent risk factors were older age, JMs, higher fasting blood glucose, alanine aminotransferase (ALT), and lower high density lipoprotein (HDL)-cholesterol. Conclusions The prevalence of GD was significantly lower in JNs than in JMs on the Jeju island. Older age, JMs, higher fasting blood glucose and ALT, and lower HDL-cholesterol contributed to the prevalence of GD among Jeju island people.