심장원성 폐부종 말티즈 견에서 Furosemide 투여에 따른 방사선상 심장 지표와 체중 감소율과의 상관관계

Abstract

This study was conducted to evaluate whether body weight changes in myxomatous mitral valve disease (MMVD) maltese dogs with cardiogenic pulmonary edema (CPE) are predictive indicators of disease cure, and to confirm the correlation with other radiographic cardiac markers. For this purpose, 48 Maltese dogs treated with furosemide constant rate infusion (CRI) were enrolled and divided into two groups according to previous administration of pimobendan and enalapril. Body weight (BW), vertebral heart score (VHS), and vertebral left atrial size (VLAS) were measured at the time of admission, and the CPE disappeared. The rate of change of these indicators was calculated. In comparison with before the cure of pulmonary edema, BW, VHS, and VLAS are decreased significantly. The average rate of weight loss was -6.89 ± 0.02%, VHS decreased by -6.19 ± 0.04%, and VLAS decreased by 5.97 ± 0.04%. In comparison between the two groups according to whether or not they took heart medication (pimobendan and enalapril), the average of Group 1, who took heart medication for the first time, was higher in both the rate of change in BW and radiographic cardiac marker. But there was no significant difference between groups. In the correlation test between the BW change rate and other indicators, most showed a positive correlation, but there was no significant difference. In conclusion, although there was no correlation between the rate of change in BW and radiographic cardiac markers, BW change and VHS and VLAS showed significant decreases in all patients treated with diuretics. Therefore, measuring BW change has potential as an index that can predict the complete cure of CPE.