미녹시딜과 코펙실 성분을 함유하는 니오좀 제형의 물성 및 경피흡수 연구

Abstract

Various drug delivery systems are being studied for effective drug delivery of active substances in the pharmaceutical and cosmetic industries. Among them, a niosome formulation was used, and minoxidil, a drug known as a hair loss treatment, and kopexil, a cosmetic raw material, a hair loss reliever, were used as drugs. Each drug was encapsulated in a niosome formulation to study physical properties and stability evaluation, and it was confirmed that there was a difference in stability depending on the surfactant HLB. The percutaneous absorption rate was compared for the control group of the niosome formulation and the gel formulation, and the minoxidil and kopexil nano-niosome showed 3 to 11 times higher percutaneous absorption rate than the control group of the gel formulation. In addition, the percutaneous absorption rate for 24 h was compared for minoxidil nano-niosome and kopexil nano -niosome, and it was confirmed that 253.78 μg/㎠ was higher in the kopexil nano-niosome. Encapsulation efficiency was measured at 28.96 ±0.12% for minoxidil nano-nosome and 30.50±0.08% for kopexill nano-nosome, and as a result of drug release, less drug release was seen in the nano-niosome formulation than in the control gel formulation. Additionally, Cryo-TEM, TGA, and DSC analyzes were performed, and based on these studies, it was shown that the niosome formulation is suitable for trapping drugs and is good as a drug delivery system when used as pharmaceutical and cosmetic formulations.