Effects of Bupivacaine Infiltration Anesthesia using Temperature- responsive Hydrogel in Dogs undergoing Celiotomy Youngrok Song

Abstract

The multimodal analgesic strategy involving local anesthesia at the incision site is effective for postoperative pain relief in dogs undergoing celiotomy. Numerous studies have been conducted on drug delivery systems, such as ez:AP® (TGel Bio, Co., Ltd., Republic of Korea), a temperature-responsive hydrogel (TRH). TRH exhibits unique properties, including transitioning from a liquid state at 2–8 °C to a gel state at above 30 °C. This study aimed to investigate whether combining TRH with bupivacaine, a commonly used local anesthetic, could prolong the analgesic effect in dogs undergoing celiotomy compared with administering bupivacaine alone. Eleven dogs that underwent celiotomy were included in this study. Bupivacaine alone or combined with TRH was used for local infiltration anesthesia. Subsequent pain assessment was conducted at 2-h intervals during the next 24 husing the short form of the Glasgow composite measure pain scale. The results showed that the sensory recovery commenced 16–22 h after a single administration of TRH combined with bupivacaine for infiltration anesthesia, with the analgesic effect lasting for more than 24 h. In the case of bupivacaine alone, both sensory recovery and the duration of the analgesic effect commenced and lasted for about 6-8 h. This study revealed that the use of bupivacaine combined with TRH for local infiltration anesthesia during celiotomy can extend the duration of local analgesic effects, thus providing substantial benefits in postoperative pain management.|장될 수 있는지 조사하였다. 본 연구에서는 총 11마리의 개에서 정중개복술을 진행하였으며 부피바카인 단독 혹은 TRH와 혼합한 부피바카인을 이용하여 국소 침윤 마취를 실시하였다. 이후 24시간 동안 2시간 간격으로 the short form of the Glasgow composite measure pain scale을 이용하여 통증을 평가하였다. 결과적으로, TRH와 부피바카인을 사용한 한 번의 국소 침윤 마취 후 16-22시간 이내에 감각 회복이 시작되며, 진통 효과는 24시간 이상 지속되었다. 본 연구에서는 개에서 정중개복술 시 부피바카인과 TRH를 혼합하여 국소 침윤마취 시 국소 진통 효과의 지속 시간을 연장시킬 수 있는 것으로 생각되며, 이는 수술 후 통증 관리에 다양하고 중요한 이점을 가져다줄 수 있다.