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Effects of Ecklonia cava on Plasma and Liver Lipids, Platelet Aggregation and RBC Membrane Stability in Rats Fed Cholesterol Diet

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Author(s)
엽완정
Issued Date
2010
URI
http://dcoll.jejunu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000004935
Abstract
We compared bioactivity of 10% Ecklonia cava (EC) powder, 5% extract (carbohydrase hydrolyzed product) and 3% Dieckol (EC polyphenol) in aspect of antiobese, hypolipidemic, antiplatelet and antioxidant on RBC membrane and TBARS production in rats fed cholesterol diets.
The final weight with low food efficiency ratio in rats fed Dieckol was significantly decreased compared with the control (p<0.05). Plasma total cholesterol was significantly decreased in EC powder (p<0.05) and HDL-cholesterol was significantly decreased in Dieckol (p<0.05) both compared with the control. Liver total cholesterol significantly decreased in EC powder compared with EC extract (p<0.05) and liver TG was significantly decreased in Dieckol compared with control (p<0.05). Platelet aggregation both in initial slope and the maximum was significantly decreased in Dieckol compared with the control (both, p<0.05). Hemolysis both with and without AAPH treatment was significantly low in EC extract compared with other groups (p<0.05), but erythrocyte Na leak increase after AAPH treatment was significantly high in EC extract compared with other groups (p<0.05). Platelet rich plasma (PRP) and liver TBARS productions were decreased in all EC groups, and PRP TBARS was significantly decreased in Dieckol compared with the control. GOT compared with the control and GPT compared with Dieckol were significantly decreased in rats fed EC powder (p<0.05).
In conclusion, polyphenol rich Dieckol from Ecklonia cava seems to have some favorable effects in weight gain, platelet aggregation, RBC membrane stability and lipid peroxidation, but it is not clear how it acts at this point.
Affiliation
제주대학교 대학원
Department
대학원 식품영양학과
Advisor
강정숙
Awarded Date
2010. 2
Table Of Contents
Ⅰ. INTRODUCTION 1
Ⅱ. LITERATURE REVIEW 3
1. Antioxidant and physiological functions 3
2. Plant fiber and physiological roles 4
Ⅲ. MATERIAL & METHOD 7
1. Animal and diet 7
2. Analysis of sample 9
1) Whole blood platelet aggregation 9
2) Plasma HDL-cholesterol, Total cholesterol and Triglyceride 9
3) Liver Total cholesterol & Triglyceride 10
4) Erythrocyte Na-leak 12
5) PRP TBARS production 14
6) Liver TBARS production 14
7) Protein analysis 14
8) Measurement of hemolysis 15
9) Statistical analysis 15
Ⅳ. RESULTS & DISCUSSIONS 16
1. Weight gain and food efficiency 16
2. Plasma total-cholesterol, HDL-cholesterol, triglyceride and glucose 19
3. Liver cholesterol and triglyceride 22
4. Whole blood platelet aggregation 24
5. Hemolysis and erythrocyte Na leak 27
6. Liver and PRP TBARS production 30
7. GOT & GPT 32
Ⅴ. CONCLUSION 34
Ⅵ. REFERENCES 36
Degree
Master
Publisher
제주대학교 대학원
Citation
엽완정. (2010). Effects of Ecklonia cava on Plasma and Liver Lipids, Platelet Aggregation and RBC Membrane Stability in Rats Fed Cholesterol Diet
Type
Dissertation
Appears in Collections:
General Graduate School > Food Science and Nutrition
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