2 - Methoxy - 4-vinylphenol induced attenuation of cell migration in pancreatic cancer cells.

Abstract

Pancreatic cancer is the most dangerous cancer, because it is difficult to diagnose and moves easily to other organs. Also, no relevant therapeutics have been developed; so there is a need for research on the treatment agents of pancreatic cancer. 2-Methoxy-4-vinyl phenol (2M4VP) is a flavoring compound with properties such as cycle arrest and anti-inflammation. In this study, we confirmed 2M4VP anticancer effects on pancreatic cancer-cell lines, including Panc-1 and SNU-213cells. 2M4VP reduced the viability of Panc-1 cells by inhibiting the proliferation of cell nuclear antigen (PCNA) protein. 2M4VP also suppressed the migratory activity of Panc-1 and SNU-213 cells. In addition, we demonstrated that the treatment with 2M4VP effectively decreased the phosphorylation of Focal Adhesion Kinase (FAK) and AKT pathways. These results suggest that 2M4VP might be used as a pancreatic cancer treatment supplement.