Ceramide NP를 함유한 PLO gel에서 형성되는 액정에 관한 연구

Abstract

The stratum corneum is formed as a cytoplasm with keratin cells and lamella structures, and among them, the main ingredient of intercellular lipid is seramide. Ceramide is a lipid that occurs naturally in the skin, and it can be said that the stratum corneum is the most important ingredient in forming a lamella structure. The stratum corneum has the advantage of preventing foreign matter or irritation from the outside and inhibiting moisture evaporation in the skin, which can be expected to have a positive effect on skin moisturization and elasticity. However, because ceramide is an insoluble substance, it is not suitable for direct application to the skin, so it was intended to apply it to the pluronic lecithin organogel (PLO gel) formulation, which draws constant attention among drug delivery systems used for skin permeation and absorption. A solubility experiment on the oil of the ceramide was conducted to select a suitable oil. Changes in room temperature (25 ℃), cold temperature (5 ℃) and constant temperature (40 ℃) of PLO gel containing selected oil and Ceramide were observed, and formation and stability of the liquid crystal were observed using polarizing microscope and nanozetasizer. In addition, small-angle X-ray scanning (SAXS) and wide-angle X-ray scanning (WAXS) were conducted to check the structure in the PLO gel, and Differential scanning calorimetry (DSC) and viscosity analysis were also conducted to check the materiality of the PLO gel. According to the content ratio of ceramide and lecithin in the PLO gel, there were differences in the formation of liquid crystals and the size and stability of the liquid crystals. In addition, through SAXS and WAXS analysis, it was confirmed that the PLO gel containing no ceramide has a hexagonal structure, and the PLO gel containing ceramide has a lamella structure.